2. Signaling Pathways
  3. PROTAC
  4. Target Protein Ligand-Linker Conjugates

Target Protein Ligand-Linker Conjugates

Target Protein Ligand-Linker Conjugates

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Target Protein Ligand-Linker Conjugate incorporates a ligand for the target protein and a linker. When binding to an E3 ligase ligand, the conjugate will be a PROTAC with ability to induce ubiquitylation and subsequent degradation the protein of interest.

Target proteins are usually proteins whose overexpression or accumulation may play important roles in the progress of diseases. Numbers of PROTACs have been developed to degrade kinases, transcription factors, epigenetic tools and E3 ligase themselves.

The optimal lengths of the PROTAC linkers are reported varying from 12-carbon to over 20-carbon, and the commonly used linkers in the development of PROTACs are PEGs, Alkyl-Chain and Alkyl/ether.

Target Protein Ligand-Linker Conjugates Related Products (114):

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-180179
    BLIMP-1 ligand-Linker Conjugate 1
    BLIMP-1 Ligand-Linker Conjugate 1 is a conjugate of BLIMP-1 Ligand-1 (HY-180178) and Linker (HY-180180). BLIMP-1 ligand-Linker Conjugate 1 can be coupled with CRBN ligand-881 (HY-W442918) to form PROTAC BLIMP-1 degrader-1 (HY-180177).
    BLIMP-1 ligand-Linker Conjugate 1
  • HY-176802
    Oxide-DFHBI-demethyl-C6-NH2
    Oxide-DFHBI-demethyl-C6-NH2 is a Target Protein Ligand-Linker Conjugate that incorporates a target aptamer ligand (HY-176801) and a PROTAC linker (HY-79577), which recruits E3 ligases. Oxide-DFHBI-demethyl-C6-NH2 can be used for synthesis of RNA aptamer-based PROTAC Dth (HY-175397).
    Oxide-DFHBI-demethyl-C6-NH2
  • HY-176797
    SMARCA2/4 Ligand-Linker Conjugate 2 2380272-29-5
    SMARCA2/4 Ligand-Linker Conjugate 2 is a target protein ligand-linker conjugate that can be used to synthesize PROTAC AU-15330 (HY-145388).
    SMARCA2/4 Ligand-Linker Conjugate 2
  • HY-178311
    EGFR Ligand-Linker Conjugates 4 2654824-18-5
    EGFR Ligand-Linker Conjugates 4 is a conjugate of the EGFR ligand (HY-178313) and the linker. EGFR Ligand-Linker Conjugates 4 can be used for synthesizing PROTAC EGFR degrader 16 (HY-178242).
    EGFR Ligand-Linker Conjugates 4
  • HY-170854
    RET Ligand-Linker Conjugate-1
    RET Ligand-Linker Conjugate-1 is the conjugate composed of a RET ligand and a linker. RET Ligand-Linker Conjugate-1 can be used for synthesis of QZ2135 (HY-170852).
    RET Ligand-Linker Conjugate-1
  • HY-163019
    EN884 2189497-60-5
    EN884 is a BRD4 degrader via a SKP1- and proteasome-dependent manner. EN884 can be used in synthetic proteolysis targeting chimeras (PROTACs).
    EN884
  • HY-175551
    HPK1 ligand-Linker Conjugate 1 3061690-80-7
    HPK1 ligand-Linker Conjugate 1 is a synthesized target protein ligand-linker conjugate that can be used for synthesis of PROTACs, such as PROTAC HPK1 Degrader-5 (HY-175547). PROTAC HPK1 Degrader-5 is a potent and orally active HPK1 PROTAC degrader with anti-tumor activity.
    HPK1 ligand-Linker Conjugate 1
  • HY-178519
    JQ-1 (carboxylic acid)-NH-C8-COOH 2918972-18-4
    JQ-1 (carboxylic acid)-NH-C8-COOH is a synthetic target protein ligand-conjugate linker, which can be used to synthesize JQ1-S(GlcNAc)Cq (HY-178510). JQ1-S(GlcNAc)Cq is a potent Sugar-Coated PROTAC bifunctional degrader with anti-tumor activity.
    JQ-1 (carboxylic acid)-NH-C8-COOH
  • HY-182018
    ATR ligand 2-CO-Ph-COOH
    ATR ligand 2-CO-Ph-COOH (Compound 39) is a Target Protein Ligand-Linker Conjugate that incorporates a ligand for ATR (HY-182017) and a PROTAC linker, which recruits E3 ligases. can be used for synthesis of PROTAC ATR degrader-3 (HY-182016).
    ATR ligand 2-CO-Ph-COOH
  • HY-176364
    AZD9496-O-C3-O-C3-O-C-acid 2361117-48-6
    AZD9496-O-C3-O-C3-O-C-acid is a Target Protein Ligand-Linker Conjugate that incorporates a ligand for ERα (HY-12870) and a PROTAC linker, which recruits E3 ligases. AZD9496-O-C3-O-C3-O-C-acid can be used for synthesis of PROTAC AZ'6421 (HY-135312).
    AZD9496-O-C3-O-C3-O-C-acid
  • HY-174409
    HDAC6 ligand-Linker Conjugate 1
    HDAC6 ligand-linker conjugate 1 is a conjugate of HDAC6 ligand and linker, which can be used to synthesize PROTACs such as PROTAC HDAC6 degrader 5 (HY-174401).
    HDAC6 ligand-Linker Conjugate 1
  • HY-168682
    Adamantane-Butyl alcohol 31685-38-8
    Adamantane-Butyl alcohol is a selective and persistent degrader targeting the CDK8-cyclin C complex. Adamantane-Butyl alcohol is the linker for LL-K8-22 (PROTAC CDK8-cyclin C, HY-149209) and HyT.
    Adamantane-Butyl alcohol
  • HY-179299
    POI ligand-2-NH-C10H20-NH-Boc
    POI ligand-2-NH-C10H20-NH-Boc is a target protein ligand linker conjugate that contains a GPX4 ligand (HY-179294) and a PROTAC linker (HY-W047688), which can recruit E3 ligases. POI ligand-2-NH-C10H20-NH-Boc can be used for synthesis of PROTAC GPX4 degrader-5 (HY-178925).
    POI ligand-2-NH-C10H20-NH-Boc
  • HY-159777
    JQ-1-PEG5-Alkyne
    CPI-203-PEG5-Alkyne is a conjugate of target protein ligase and linker. CPI-203-PEG5-Alkyne can be used for synthesis of PROTAC BRD4-DCAF1 degrader-1 (HY-169151).
    JQ-1-PEG5-Alkyne
  • HY-175333
    c-Met ligand-Linker Conjugate 1
    c-Met ligand-Linker Conjugate 1 is an Target Protein Ligand-Linker Conjugate that incorporates a ligand for c-Met (HY-W425461) and a PROTAC linker (HY-151862), which recruits E3 ligases. c-Met ligand-Linker Conjugate 1 can be used for synthesis of PROTAC c-Met degrader-5 (HY-175320).
    c-Met ligand-Linker Conjugate 1
  • HY-175726
    BRAF ligand-Linker Conjugate 1 3094183-96-4
    BRAF ligand-Linker Conjugate 1 is a target protein ligand-linker conjugate that can be used to synthesize PROTAC CST905(HY-175435).
    BRAF ligand-Linker Conjugate 1
  • HY-42429
    CPI-203-PEG1-C3-O-COOH 1997304-12-7
    CPI-203-PEG1-C3-O-COOH is a conjugate of the BRD4 ligand (HY-78695) and the linker (HY-42427). CPI-203-PEG1-C3-O-COOH can be used for synthesizing PROTAC BRD4 degrader ARV-771 (HY-100972).
    CPI-203-PEG1-C3-O-COOH
  • HY-174357
    HPK1 ligand 3-dimethylph tetrahydropyridine
    HPK1 ligand 3-dimethylph tetrahydropyridine is a Target Protein Ligand-Linker Conjugate. HPK1 ligand 3-dimethylph tetrahydropyridine can be used to synthesize PROTAC HPK1 Degrader-4 (HY-174135).
    HPK1 ligand 3-dimethylph tetrahydropyridine
  • HY-180982
    Asciminib-NH2 3106065-83-9
    Asciminib-NH2 is a BCR-ABL ligand and can be used for the synthesis of PROTACs, such as P19As (HY-180981).
    Asciminib-NH2
  • HY-180852
    ER ligand-14-PEG3-Boc
    ER ligand-14-PEG3-Boc is a conjugate of a target protein ligand and linker, composed of an estrogen receptor ligand and a corresponding linker. ER ligand-14-PEG3-Boc can be used to synthesize PROTACs such as ERB-2 (HY-180850). ERB-2 exhibits good antiproliferative activity against Osimertinib (HY-15772)-resistant non-small cell lung cancer.
    ER ligand-14-PEG3-Boc